Research workbench

ZHD/H242A complex with bZOL

Analyse ZHD/H242A complex with bZOL in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6JR5
Type: protein
Length: 535 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.08
Source: Clonostachys rosea
Molecule: Zearalenone hydrolase
Ligands: ZHB
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · resolution 2.08 · 2 distinct chains · 51% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Zearalenone hydrolase	protein	268	51% helix, 18% strand	—
B	Zearalenone hydrolase	protein	267	50% helix, 18% strand	—

Ligands and binding sites

ZHB · (3S,7S,11E)-7,14,16-trihydroxy-3-methyl-3,4,5,6,7,8,9,10-octahydro-1H-2-benzoxacyclotetradecin-1-one · ligand · 2 copies · chains A, B
GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	349	0.76	0.86	35	ZHB, GOL
2	349	0.74	0.85	37	ZHB, GOL

Interfaces

1 interface between chains.

A–B · 669 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6JR5 · ZHD/H242A complex with bzol · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6JR5 · PDBe 6JR5

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.