Research workbench
Crystal structure of YFV-17D sE in postfusion state
Analyse Crystal structure of YFV-17D sE in postfusion state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6IW1
- Type
- protein
- Length
- 1,132 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.1
- Source
- Yellow fever virus (strain 17D vaccine)
- Molecule
- Envelope protein E
- UniProt
- P03314
- Pockets
- 18 · best druggability 0.88
Structure
x-ray diffraction · resolution 3.1 · 3 distinct chains · 8% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Envelope protein E | protein | 377 | 7% helix, 54% strand | P03314 |
| B | Envelope protein E | protein | 380 | 8% helix, 54% strand | P03314 |
| C | Envelope protein E | protein | 375 | 8% helix, 55% strand | P03314 |
Pockets
18 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1128 | 0.88 | 0.90 | 117 | empty |
| 2 | 364 | 0.72 | 0.84 | 50 | empty |
| 3 | 69 | 0.71 | 0.96 | 21 | empty |
| 4 | 429 | 0.69 | 0.81 | 50 | empty |
| 5 | 311 | 0.67 | 0.82 | 34 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2208 Ų buried · 28 hydrogen bonds · protein-protein
- A–C · 2200 Ų buried · 28 hydrogen bonds · protein-protein
- B–C · 2192 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide (disulfide).
Compared structures
- 6IW1 · Crystal structure of yfv-17D se in postfusion state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03314
- Elsewhere: RCSB PDB 6IW1 · PDBe 6IW1 · UniProt P03314
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.