Research workbench
Crystal structure of Homoserine O-acetyltransferase in complex with Homoserine from Mycobacterium smegmatis ATCC 19420
Analyse Crystal structure of Homoserine O-acetyltransferase in complex with Homoserine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6IOH
- Type
- protein
- Length
- 741 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2
- Source
- Mycobacterium smegmatis
- Molecule
- Homoserine O-acetyltransferase
- EC
- 2.3.1.31
- UniProt
- A0A0D6HE46
- Ligands
- HSE
- Pockets
- 5 · best druggability 0.67
Structure
x-ray diffraction · resolution 2 · 2 distinct chains · 39% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Homoserine O-acetyltransferase (EC 2.3.1.31) | protein | 375 | 39% helix, 18% strand | A0A0D6HE46 |
| B | Homoserine O-acetyltransferase (EC 2.3.1.31) | protein | 366 | 39% helix, 18% strand | A0A0D6HE46 |
Ligands and binding sites
- HSE · L-homoserine · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 334 | 0.67 | 0.81 | 41 | HSE |
| 2 | 319 | 0.66 | 0.81 | 36 | empty |
| 3 | 300 | 0.66 | 0.81 | 40 | HSE |
| 4 | 160 | 0.53 | 0.80 | 29 | empty |
| 5 | 150 | 0.49 | 0.78 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 2048 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
- 6IOH · Crystal structure of homoserine O-acetyltransferase in complex with homoserine from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0D6HE46
- Elsewhere: RCSB PDB 6IOH · PDBe 6IOH · UniProt A0A0D6HE46
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.