Research workbench
Crystal structure of human CAP-G in complex with CAP-H
Analyse Crystal structure of human CAP-G in complex with CAP-H in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6IGX
- Type
- protein
- Length
- 1,560 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.995
- Source
- Homo sapiens
- Molecule
- Condensin complex subunit 3; Condensin complex subunit 2
- UniProt
- Q9BPX3, Q15003
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · resolution 2.995 · 4 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Condensin complex subunit 3 | protein | 730 | 72% helix, 0% strand | Q9BPX3 |
| A | Condensin complex subunit 2 | protein | 50 | 24% helix, 4% strand | Q15003 |
| D | Condensin complex subunit 3 | protein | 731 | 73% helix, 0% strand | Q9BPX3 |
| C | Condensin complex subunit 2 | protein | 49 | 14% helix, 4% strand | Q15003 |
Ligands and binding sites
- EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 899 | 0.75 | 0.78 | 77 | empty |
| 2 | 71 | 0.48 | 0.83 | 15 | empty |
| 3 | 131 | 0.40 | 0.75 | 16 | empty |
| 4 | 88 | 0.36 | 0.75 | 17 | empty |
| 5 | 56 | 0.29 | 0.75 | 13 | empty |
Interfaces
4 interfaces between chains.
- B–A · 2318 Ų buried · 26 hydrogen bonds · protein-protein
- D–C · 2263 Ų buried · 27 hydrogen bonds · protein-protein
- B–D · 286 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 43 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6IGX · Crystal structure of human cap-G in complex with cap-H · the same entry in another collection · chain D against D, TM-score 1.00
- Q9BPX3 · AlphaFold monomer V2.0 prediction for condensin complex subunit 3 (Q9BPX3) · a predicted model of the same protein · chain D against A, TM-score 0.89
- Q15003 · AlphaFold monomer V2.0 prediction for condensin complex subunit 2 (Q15003) · a predicted model of the same protein · chain C against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BPX3
- Every structure of UniProt Q15003
- Elsewhere: RCSB PDB 6IGX · PDBe 6IGX · UniProt Q9BPX3 · UniProt Q15003
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