Research workbench
Circular permutant of ribosomal protein S6, swap helix 2, L75A mutant
Analyse Circular permutant of ribosomal protein S6, swap helix 2, L75A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6I6O
- Type
- protein
- Length
- 410 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.9
- Source
- Thermus thermophilus HB8
- Molecule
- 30S ribosomal protein S6,30S ribosomal protein S6
- UniProt
- Q5SLP8
- Pockets
- 5 · best druggability 0.86
Structure
x-ray diffraction · resolution 1.9 · 4 distinct chains · 31% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 30S ribosomal protein S6,30S ribosomal protein S6 | protein | 99 | 29% helix, 45% strand | Q5SLP8 |
| B | 30S ribosomal protein S6,30S ribosomal protein S6 | protein | 106 | 33% helix, 42% strand | Q5SLP8 |
| C | 30S ribosomal protein S6,30S ribosomal protein S6 | protein | 105 | 35% helix, 43% strand | Q5SLP8 |
| D | 30S ribosomal protein S6,30S ribosomal protein S6 | protein | 100 | 26% helix, 45% strand | Q5SLP8 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1114 | 0.86 | 0.87 | 112 | empty |
| 2 | 155 | 0.80 | 0.96 | 25 | empty |
| 3 | 197 | 0.72 | 0.88 | 32 | empty |
| 4 | 119 | 0.44 | 0.77 | 25 | empty |
| 5 | 92 | 0.39 | 0.76 | 22 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1688 Ų buried · 24 hydrogen bonds · protein-protein
- B–D · 1546 Ų buried · 23 hydrogen bonds · protein-protein
- A–D · 888 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 282 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 175 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6I6O · Circular permutant of ribosomal protein S6, swap helix 2, L75A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SLP8
- Elsewhere: RCSB PDB 6I6O · PDBe 6I6O · UniProt Q5SLP8
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