Research workbench
Heteromeric tandem IgG4/IgG1 Fc
Analyse Heteromeric tandem IgG4/IgG1 Fc in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HYG
- Type
- protein
- Length
- 416 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.31
- Source
- Homo sapiens
- Molecule
- IgHG1 and IgHG4 hybrid
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.39
Structure
x-ray diffraction · resolution 2.31 · 1 distinct chain · 11% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | IgHG1 and IgHG4 hybrid | protein | 416 | 11% helix, 48% strand | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 131 | 0.39 | 0.74 | 27 | empty |
| 2 | 53 | 0.30 | 0.76 | 19 | empty |
| 3 | 62 | 0.29 | 0.75 | 16 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6HYG · Heteromeric tandem IGG4/IGG1 Fc · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6HYG · PDBe 6HYG
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