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Crystal structure of the head and coiled-coil domains of zebrafish CCDC61

Analyse Crystal structure of the head and coiled-coil domains of zebrafish CCDC61 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6HXY
Type
protein
Length
300 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
2.9
Source
Danio rerio
Molecule
Coiled-coil domain-containing protein 61
UniProt
Q08CF3
Pockets
2 · best druggability 0.52

Structure

x-ray diffraction · resolution 2.9 · 2 distinct chains · 35% helix, 38% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ACoiled-coil domain-containing protein 61protein14735% helix, 39% strandQ08CF3
BCoiled-coil domain-containing protein 61protein15335% helix, 37% strandQ08CF3

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11370.520.8018empty
21030.460.8017empty

Interfaces

1 interface between chains.

  • A–B · 936 Ų buried · 4 hydrogen bonds · protein-protein

Compared structures

  • 6HXY · Crystal structure of the head and coiled-coil domains of zebrafish CCDC61 · the same entry in another collection · chain A against A, TM-score 1.00
  • Q08CF3 · AlphaFold monomer V2.0 prediction for centrosomal protein CCDC61 (Q08CF3) · a predicted model of the same protein · chain B against A, TM-score 0.97

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