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NMR structure of the pro-inflammatory cytokine interleukin-36alpha

Analyse NMR structure of the pro-inflammatory cytokine interleukin-36alpha in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6HPI
Type: protein
Length: 158 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: NOT
Source: Homo sapiens
Molecule: Interleukin-36 alpha
UniProt: Q9UHA7
Pockets: 2 · best druggability 0.73

Structure

solution nmr · resolution NOT · 1 distinct chain · 8% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-36 alpha	protein	158	8% helix, 34% strand	Q9UHA7

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.73	0.97	23	empty
2	132	0.41	0.75	26	empty

Compared structures

6HPI · NMR structure of the pro-inflammatory cytokine interleukin-36ALPHA · the same entry in another collection · chain A against A, TM-score 1.00
Q9UHA7 · AlphaFold monomer V2.0 prediction for interleukin-36 alpha (Q9UHA7) · a predicted model of the same protein · chain A against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UHA7
Elsewhere: RCSB PDB 6HPI · PDBe 6HPI · UniProt Q9UHA7

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