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Structure of Hgh1, crystal form II

Analyse Structure of Hgh1, crystal form II in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6HB3
Type: protein
Length: 1,434 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3
Source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Molecule: Protein HGH1
UniProt: P48362
Pockets: 13 · best druggability 0.57

Structure

x-ray diffraction · resolution 3 · 3 distinct chains · 64% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	Protein HGH1	protein	358	64% helix, 2% strand	P48362
B	Protein HGH1	protein	360	64% helix, 2% strand	P48362
C	Protein HGH1	protein	358	64% helix, 2% strand	P48362

Pockets

13 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	374	0.57	0.75	43	empty
2	170	0.45	0.75	20	empty
3	178	0.45	0.75	27	empty
4	90	0.43	0.79	22	empty
5	86	0.42	0.79	22	empty

Interfaces

3 interfaces between chains.

C–D · 584 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 578 Å² buried · 7 hydrogen bonds · protein-protein
A–D · 556 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6HB3 · Structure of HGH1, crystal form II · the same entry in another collection · chain A against A, TM-score 1.00
P48362 · AlphaFold monomer V2.0 prediction for protein HGH1 (P48362) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48362
Elsewhere: RCSB PDB 6HB3 · PDBe 6HB3 · UniProt P48362

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