Research workbench
Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 1.
Analyse Influenza A nucleoprotein docked into 3D helical structure of the wild type… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6H9G
- Type
- protein
- Length
- 802 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 11.0
- Source
- Influenza A virus; Influenza A virus (strain A/Wilson-Smith/1933 H1N1)
- Molecule
- Nucleoprotein; Polypeptide loop
- UniProt
- Q1K9H2
- Pockets
- 13 · best druggability 0.50
Structure
electron microscopy · resolution 11.0 · 2 distinct chains · 45% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Nucleoprotein | protein | 382 | 47% helix, 8% strand | Q1K9H2 |
| B, D | Polypeptide loop | protein | 19 | 0% helix, 16% strand | — |
Pockets
13 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 159 | 0.50 | 0.78 | 30 | empty |
| 2 | 105 | 0.43 | 0.78 | 20 | empty |
| 3 | 115 | 0.42 | 0.76 | 19 | empty |
| 4 | 96 | 0.38 | 0.76 | 21 | empty |
| 5 | 62 | 0.37 | 0.79 | 13 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1593 Ų buried · 30 hydrogen bonds · protein-protein
- C–D · 1591 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 6H9G · Influenza a nucleoprotein docked into 3D helical structure of the wild type… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q1K9H2
- Elsewhere: RCSB PDB 6H9G · PDBe 6H9G · UniProt Q1K9H2
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