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Crystal structure of a C-terminal MIF4G domain in NOT1

Analyse Crystal structure of a C-terminal MIF4G domain in NOT1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6H3Z
Type: protein
Length: 415 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3
Source: Chaetomium thermophilum var. thermophilum DSM 1495
Molecule: CCR4-not transcription complex subunit 1
UniProt: G0SAL9
Ligands: NA
Pockets: 2 · best druggability 0.70

Structure

x-ray diffraction · resolution 3 · 2 distinct chains · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CCR4-not transcription complex subunit 1	protein	208	72% helix, 0% strand	G0SAL9
B	CCR4-not transcription complex subunit 1	protein	207	71% helix, 0% strand	G0SAL9

Ligands and binding sites

NA · Sodium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	715	0.70	0.77	52	empty
2	51	0.27	0.74	8	empty

Interfaces

1 interface between chains.

A–B · 438 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6H3Z · Crystal structure of a C-terminal MIF4G domain in NOT1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0SAL9
Elsewhere: RCSB PDB 6H3Z · PDBe 6H3Z · UniProt G0SAL9

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