Research workbench
Structure of Ferric uptake regulator from Pseudomonas aeruginosa with manganese.
Analyse Structure of Ferric uptake regulator from Pseudomonas aeruginosa with manganese. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6H1C
- Type
- protein
- Length
- 266 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.34
- Source
- Pseudomonas aeruginosa PAO1
- Molecule
- Ferric uptake regulation protein
- UniProt
- Q03456
- Ligands
- ZN, MN
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · resolution 2.34 · 2 distinct chains · 42% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ferric uptake regulation protein | protein | 132 | 41% helix, 17% strand | Q03456 |
| B | Ferric uptake regulation protein | protein | 134 | 43% helix, 16% strand | Q03456 |
Ligands and binding sites
- ZN · Zinc ion · metal · 12 copies · chains A, B
- MN · Manganese (II) ion · metal · 11 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 615 | 0.67 | 0.77 | 68 | ZN |
| 2 | 121 | 0.42 | 0.76 | 24 | ZN |
Interfaces
1 interface between chains.
- A–B · 397 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6H1C · Structure of ferric uptake regulator from pseudomonas aeruginosa with manganese. · the same entry in another collection · chain A against A, TM-score 1.00
- Q03456 · AlphaFold monomer V2.0 prediction for ferric uptake regulation protein (Q03456) · a predicted model of the same protein · chain B against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03456
- Elsewhere: RCSB PDB 6H1C · PDBe 6H1C · UniProt Q03456
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