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Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with AMPCP

Analyse Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6GQS
Type: protein
Length: 233 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.43
Source: Homo sapiens
Molecule: Heat shock protein HSP 90-alpha
UniProt: P07900
Ligands: A12, MG
Pockets: 1 · best druggability 0.62

Structure

x-ray diffraction · resolution 1.43 · 1 distinct chain · 39% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock protein HSP 90-alpha	protein	233	39% helix, 21% strand	P07900

Ligands and binding sites

A12 · Phosphomethylphosphonic acid adenosyl ester · ligand · chains A
MG · Magnesium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	227	0.62	0.82	27	A12, MG

Compared structures

6GQS · Structure of human heat shock protein 90-alpha N-terminal domain (HSP90-ntd) variant… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07900
Elsewhere: RCSB PDB 6GQS · PDBe 6GQS · UniProt P07900

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