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Crystal structure of Human ARS2 residues 147-270 + 408-763 with deletion of loop B
Analyse Crystal structure of Human ARS2 residues 147-270 + 408-763 with deletion of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6F7S
- Type
- protein
- Length
- 862 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.37
- Source
- Homo sapiens
- Molecule
- Serrate RNA effector molecule homolog; Serrate RNA effector molecule homolog,Serrate RNA…
- UniProt
- Q9BXP5
- Pockets
- 8 · best druggability 0.81
Structure
x-ray diffraction · resolution 3.37 · 4 distinct chains · 51% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serrate RNA effector molecule homolog | protein | 122 | 72% helix, 1% strand | Q9BXP5 |
| C | Serrate RNA effector molecule homolog,Serrate RNA effector molecule homolog | protein | 319 | 42% helix, 16% strand | Q9BXP5 |
| B | Serrate RNA effector molecule homolog | protein | 121 | 73% helix, 1% strand | Q9BXP5 |
| D | Serrate RNA effector molecule homolog,Serrate RNA effector molecule homolog | protein | 300 | 43% helix, 17% strand | Q9BXP5 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1020 | 0.81 | 0.83 | 73 | empty |
| 2 | 628 | 0.67 | 0.76 | 36 | empty |
| 3 | 315 | 0.65 | 0.81 | 30 | empty |
| 4 | 361 | 0.62 | 0.78 | 39 | empty |
| 5 | 70 | 0.47 | 0.84 | 19 | empty |
Interfaces
4 interfaces between chains.
- A–C · 3049 Ų buried · 32 hydrogen bonds · protein-protein
- B–D · 2999 Ų buried · 28 hydrogen bonds · protein-protein
- C–D · 603 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 191 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6F7S · Crystal structure of human ARS2 residues 147-270 + 408-763 with deletion of loop B · the same entry in another collection · chain D against D, TM-score 1.00
- Q9BXP5 · AlphaFold monomer V2.0 prediction for serrate RNA effector molecule homolog (Q9BXP5) · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BXP5
- Elsewhere: RCSB PDB 6F7S · PDBe 6F7S · UniProt Q9BXP5
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