Research workbench
Crystal structure of Human ARS2 residues 147-270 + 408-763
Analyse Crystal structure of Human ARS2 residues 147-270 + 408-763 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6F7P
- Type
- protein
- Length
- 874 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.7
- Source
- Homo sapiens
- Molecule
- Serrate RNA effector molecule homolog
- UniProt
- Q9BXP5
- Pockets
- 8 · best druggability 0.70
Structure
x-ray diffraction · resolution 3.7 · 4 distinct chains · 52% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serrate RNA effector molecule homolog | protein | 121 | 74% helix, 1% strand | Q9BXP5 |
| C | Serrate RNA effector molecule homolog | protein | 316 | 44% helix, 17% strand | Q9BXP5 |
| B | Serrate RNA effector molecule homolog | protein | 122 | 74% helix, 1% strand | Q9BXP5 |
| D | Serrate RNA effector molecule homolog | protein | 315 | 44% helix, 17% strand | Q9BXP5 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 827 | 0.70 | 0.76 | 49 | empty |
| 2 | 790 | 0.69 | 0.76 | 44 | empty |
| 3 | 171 | 0.56 | 0.81 | 26 | empty |
| 4 | 221 | 0.52 | 0.76 | 27 | empty |
| 5 | 191 | 0.50 | 0.77 | 27 | empty |
Interfaces
5 interfaces between chains.
- A–C · 3032 Ų buried · 24 hydrogen bonds · protein-protein
- B–D · 3019 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 320 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 260 Ų buried · 0 hydrogen bonds · protein-protein
- C–B · 114 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6F7P · Crystal structure of human ARS2 residues 147-270 + 408-763 · the same entry in another collection · chain D against D, TM-score 1.00
- Q9BXP5 · AlphaFold monomer V2.0 prediction for serrate RNA effector molecule homolog (Q9BXP5) · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BXP5
- Elsewhere: RCSB PDB 6F7P · PDBe 6F7P · UniProt Q9BXP5
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