Research workbench

Oligomeric complex of a Hsp27 24-mer at 3.6 A resolution

Analyse Oligomeric complex of a Hsp27 24-mer at 3.6 A resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6DV5
Type: protein
Length: 4,036 residues
Chains: 24
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.58
Source: Homo sapiens
Molecule: Heat shock protein beta-1
UniProt: P04792
Pockets: 20 · best druggability 0.83

Structure

x-ray diffraction · resolution 3.58 · 24 distinct chains · 5% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Heat shock protein beta-1	protein	156	5% helix, 27% strand	P04792
A	Heat shock protein beta-1	protein	181	4% helix, 22% strand	P04792
D	Heat shock protein beta-1	protein	165	4% helix, 26% strand	P04792
F	Heat shock protein beta-1	protein	163	3% helix, 21% strand	P04792
H	Heat shock protein beta-1	protein	160	8% helix, 24% strand	P04792
J	Heat shock protein beta-1	protein	162	5% helix, 26% strand	P04792
L	Heat shock protein beta-1	protein	165	10% helix, 22% strand	P04792
N	Heat shock protein beta-1	protein	162	5% helix, 19% strand	P04792
P	Heat shock protein beta-1	protein	164	9% helix, 25% strand	P04792
R	Heat shock protein beta-1	protein	167	3% helix, 23% strand	P04792
T	Heat shock protein beta-1	protein	166	9% helix, 25% strand	P04792
V	Heat shock protein beta-1	protein	161	5% helix, 25% strand	P04792
X	Heat shock protein beta-1	protein	166	4% helix, 23% strand	P04792
C	Heat shock protein beta-1	protein	166	2% helix, 19% strand	P04792
E	Heat shock protein beta-1	protein	173	6% helix, 22% strand	P04792
G	Heat shock protein beta-1	protein	179	4% helix, 22% strand	P04792
I	Heat shock protein beta-1	protein	169	5% helix, 22% strand	P04792
K	Heat shock protein beta-1	protein	175	2% helix, 21% strand	P04792
M	Heat shock protein beta-1	protein	177	6% helix, 20% strand	P04792
O	Heat shock protein beta-1	protein	174	7% helix, 21% strand	P04792
Q	Heat shock protein beta-1	protein	161	7% helix, 24% strand	P04792
S	Heat shock protein beta-1	protein	180	3% helix, 18% strand	P04792
U	Heat shock protein beta-1	protein	175	0% helix, 19% strand	P04792
W	Heat shock protein beta-1	protein	169	3% helix, 24% strand	P04792

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1151	0.83	0.84	105	empty
2	561	0.80	0.86	77	empty
3	645	0.79	0.84	79	empty
4	845	0.79	0.82	90	empty
5	634	0.77	0.83	75	empty

Interfaces

61 interfaces between chains.

D–C · 2742 Å² buried · 40 hydrogen bonds · protein-protein
P–Q · 2708 Å² buried · 29 hydrogen bonds · protein-protein
V–W · 2701 Å² buried · 22 hydrogen bonds · protein-protein
N–O · 2596 Å² buried · 22 hydrogen bonds · protein-protein
X–I · 2574 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

6DV5 · Oligomeric complex of a HSP27 24-mer at 3.6 a resolution · the same entry in another collection · chain J against J, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04792
Elsewhere: RCSB PDB 6DV5 · PDBe 6DV5 · UniProt P04792

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.