Research workbench
Crystal Structure of an influenza A hemagglutinin antibody Fab CH65:1203d4 chimera
Analyse Crystal Structure of an influenza A hemagglutinin antibody Fab CH65:1203d4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6DLB
- Type
- protein
- Length
- 437 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.2
- Source
- Homo sapiens
- Molecule
- CH65:1203d4 Fab heavy chain; CH65:1203d4 Fab light chain
- Ligands
- SO4
- Pockets
- 7 · best druggability 0.45
Structure
x-ray diffraction · resolution 2.2 · 2 distinct chains · 8% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | CH65:1203d4 Fab heavy chain | protein | 227 | 8% helix, 49% strand | — |
| L | CH65:1203d4 Fab light chain | protein | 210 | 8% helix, 50% strand | — |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 214 | 0.45 | 0.73 | 38 | empty |
| 2 | 80 | 0.42 | 0.79 | 20 | empty |
| 3 | 115 | 0.35 | 0.73 | 20 | empty |
| 4 | 98 | 0.35 | 0.74 | 27 | empty |
| 5 | 88 | 0.33 | 0.73 | 20 | empty |
Interfaces
1 interface between chains.
- H–L · 1927 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6DLB · Crystal structure of an influenza a hemagglutinin antibody Fab CH65:1203D4 chimera · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6DLB · PDBe 6DLB
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