Research workbench

MEF2B Apo Protein Structure

Analyse MEF2B Apo Protein Structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6C9L
Type: protein
Length: 479 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.3
Source: Homo sapiens
Molecule: Myocyte-specific enhancer factor 2B
UniProt: Q02080
Pockets: 4 · best druggability 0.67

Structure

x-ray diffraction · resolution 2.3 · 5 distinct chains · 56% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	Myocyte-specific enhancer factor 2B	protein	84	54% helix, 19% strand	Q02080
B	Myocyte-specific enhancer factor 2B	protein	85	56% helix, 19% strand	Q02080
C	Myocyte-specific enhancer factor 2B	protein	85	55% helix, 19% strand	Q02080
E	Myocyte-specific enhancer factor 2B	protein	64	56% helix, 19% strand	Q02080
F	Myocyte-specific enhancer factor 2B	protein	77	58% helix, 16% strand	Q02080

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	714	0.67	0.75	57	empty
2	108	0.44	0.78	21	empty
3	70	0.36	0.77	17	empty
4	101	0.31	0.72	23	empty

Interfaces

6 interfaces between chains.

C–D · 3013 Å² buried · 42 hydrogen bonds · protein-protein
A–B · 2962 Å² buried · 39 hydrogen bonds · protein-protein
E–F · 2012 Å² buried · 25 hydrogen bonds · protein-protein
D–F · 406 Å² buried · 3 hydrogen bonds · protein-protein
A–D · 129 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

6C9L · MEF2B apo protein structure · the same entry in another collection · chain F against F, TM-score 1.00
Q02080 · AlphaFold monomer V2.0 prediction for myocyte-specific enhancer factor 2B (Q02080) · a predicted model of the same protein · chain E against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02080
Elsewhere: RCSB PDB 6C9L · PDBe 6C9L · UniProt Q02080

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.