Research workbench
Crystal Structure Of Methanobacterium Thermoautotrophicum Nicotinamide Mononucleotide Adenylyltransferase Mutant H19A complexed with NAD
Analyse Crystal Structure Of Methanobacterium Thermoautotrophicum Nicotinamide… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1M8K
- Type
- protein
- Length
- 507 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3
- Source
- Methanothermobacter thermautotrophicus
- Molecule
- Nicotinamide-nucleotide Adenylyltransferase
- EC
- 2.7.7.1
- UniProt
- O26253
- Ligands
- NAD, SO4
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · resolution 3 · 1 distinct chain · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Nicotinamide-nucleotide Adenylyltransferase (EC 2.7.7.1) | protein | 169 | 46% helix, 15% strand | O26253 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · 3 copies · chains A, B, C
- SO4 · Sulfate ion · ion · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 386 | 0.62 | 0.77 | 40 | SO4, NAD |
| 2 | 399 | 0.61 | 0.76 | 34 | SO4, NAD |
| 3 | 288 | 0.56 | 0.76 | 36 | SO4, NAD |
Interfaces
3 interfaces between chains.
- A–B · 496 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 496 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 496 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 1M8K · Crystal structure of methanobacterium thermoautotrophicum nicotinamide mononucleotide… · the same entry in another collection · chain A against A, TM-score 1.00
- O26253 · AlphaFold monomer V2.0 prediction for nicotinamide-nucleotide adenylyltransferase (O26253) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O26253
- Elsewhere: RCSB PDB 1M8K · PDBe 1M8K · UniProt O26253
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.