Research workbench
Crystal structure of peptidase E with ordered active site loop from Salmonella enterica
Analyse Crystal structure of peptidase E with ordered active site loop from Salmonella… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6A4S
- Type
- protein
- Length
- 465 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.9
- Source
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Molecule
- Peptidase E
- EC
- 3.4.13.21
- UniProt
- P36936
- Pockets
- 4 · best druggability 0.81
Structure
x-ray diffraction · resolution 1.9 · 2 distinct chains · 30% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptidase E (EC 3.4.13.21) | protein | 235 | 29% helix, 22% strand | P36936 |
| B | Peptidase E (EC 3.4.13.21) | protein | 230 | 31% helix, 22% strand | P36936 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 222 | 0.81 | 0.94 | 33 | empty |
| 2 | 206 | 0.54 | 0.79 | 23 | empty |
| 3 | 226 | 0.53 | 0.77 | 25 | empty |
| 4 | 50 | 0.25 | 0.73 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1712 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6A4S · Crystal structure of peptidase E with ordered active site loop from salmonella enterica · the same entry in another collection · chain A against A, TM-score 1.00
- P36936 · AlphaFold monomer V2.0 prediction for peptidase E (P36936) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36936
- Elsewhere: RCSB PDB 6A4S · PDBe 6A4S · UniProt P36936
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