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structure for wildtype Human prion protein (M129)

Analyse structure for wildtype Human prion protein (M129) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5YJ5
Type: protein
Length: 142 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: NOT
Source: Homo sapiens
Molecule: Major prion protein
UniProt: P04156
Pockets: 1 · best druggability 0.45

Structure

solution nmr · resolution NOT · 1 distinct chain · 46% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Major prion protein	protein	142	46% helix, 3% strand	P04156

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	104	0.45	0.79	19	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

5YJ5 · Structure for wildtype human prion protein (M129) · the same entry in another collection · chain A against A, TM-score 1.00
P04156 · AlphaFold monomer V2.0 prediction for major prion protein (P04156) · a predicted model of the same protein · chain A against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04156
Elsewhere: RCSB PDB 5YJ5 · PDBe 5YJ5 · UniProt P04156

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