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EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z2856434938
Analyse EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5RZJ
- Type
- protein
- Length
- 284 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.68
- Source
- Homo sapiens
- Molecule
- Isoform 2 of Band 4.1-like protein 3
- UniProt
- Q9Y2J2
- Ligands
- 7ZC
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · resolution 1.68 · 1 distinct chain · 36% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform 2 of Band 4.1-like protein 3 | protein | 284 | 36% helix, 26% strand | Q9Y2J2 |
Ligands and binding sites
- 7ZC · 1-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-methanamine · ligand · chains A
- EDO · 1,2-ethanediol · additive · 6 copies · chains A
- DMS · Dimethyl sulfoxide · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 475 | 0.70 | 0.81 | 53 | EDO |
| 2 | 102 | 0.42 | 0.77 | 18 | empty |
| 3 | 56 | 0.29 | 0.75 | 15 | DMS, EDO |
Compared structures
- 5RZJ · EPB41L3 pandda analysis group deposition -- crystal structure of the ferm domain of human… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y2J2 · AlphaFold monomer V2.0 prediction for band 4.1-like protein 3 (Q9Y2J2) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y2J2
- Elsewhere: RCSB PDB 5RZJ · PDBe 5RZJ · UniProt Q9Y2J2
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