Research workbench
The ENTH domain from epsin-2 in complex with phosphatidylinositol 4,5-bisphosphate (PIP2)
Analyse The ENTH domain from epsin-2 in complex with phosphatidylinositol… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5OO7
- Type
- protein
- Length
- 513 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.84
- Source
- Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
- Molecule
- SLA2
- UniProt
- G0S106
- Pockets
- 6 · best druggability 0.77
Structure
x-ray diffraction · resolution 1.84 · 2 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SLA2 | protein | 257 | 74% helix, 0% strand | G0S106 |
| B | SLA2 | protein | 256 | 70% helix, 0% strand | G0S106 |
Ligands and binding sites
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 691 | 0.77 | 0.82 | 64 | empty |
| 2 | 220 | 0.55 | 0.78 | 29 | empty |
| 3 | 192 | 0.49 | 0.76 | 27 | empty |
| 4 | 153 | 0.46 | 0.76 | 27 | empty |
| 5 | 81 | 0.40 | 0.78 | 14 | GOL |
Interfaces
1 interface between chains.
- A–B · 923 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 5OO7 · The enth domain from epsin-2 in complex with phosphatidylinositol 4,5- bisphosphate (PIP2) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S106
- Elsewhere: RCSB PDB 5OO7 · PDBe 5OO7 · UniProt G0S106
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