Research workbench
Structure of the Cascade-I-Fv complex from Shewanella putrefaciens
Analyse Structure of the Cascade-I-Fv complex from Shewanella putrefaciens in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5O7H
- Type
- protein + RNA
- Length
- 1,412 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3
- Source
- Shewanella putrefaciens (strain CN-32 / ATCC BAA-453); Shewanella putrefaciens…
- Molecule
- crRNA; CRISPR-associated protein, Csy4 family; Cas7fv; Cas5fv
- UniProt
- A4Y6G3, A4Y6G1, A4Y6G2
- Pockets
- 18 · best druggability 0.87
Structure
x-ray diffraction · resolution 3 · 6 distinct chains · 25% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | crRNA | rna | 42 | — | — |
| B | CRISPR-associated protein, Csy4 family | protein | 129 | 32% helix, 16% strand | A4Y6G3 |
| C | Cas7fv | protein | 278 | 19% helix, 34% strand | A4Y6G1 |
| D | Cas7fv | protein | 315 | 21% helix, 36% strand | A4Y6G1 |
| E | Cas7fv | protein | 312 | 23% helix, 33% strand | A4Y6G1 |
| F | Cas5fv | protein | 336 | 31% helix, 22% strand | A4Y6G2 |
Pockets
18 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1018 | 0.87 | 0.88 | 93 | empty |
| 2 | 914 | 0.85 | 0.86 | 80 | empty |
| 3 | 247 | 0.76 | 0.90 | 33 | empty |
| 4 | 284 | 0.75 | 0.88 | 34 | empty |
| 5 | 576 | 0.68 | 0.78 | 76 | empty |
Interfaces
12 interfaces between chains.
- E–F · 2646 Ų buried · 44 hydrogen bonds · protein-protein
- C–D · 2091 Ų buried · 30 hydrogen bonds · protein-protein
- A–B · 1940 Ų buried · 46 hydrogen bonds · protein-nucleic
- D–E · 1936 Ų buried · 27 hydrogen bonds · protein-protein
- A–E · 1417 Ų buried · 38 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 26 modified (engineered).
Compared structures
- 5O7H · Structure of the cascade-I-fv complex from shewanella putrefaciens · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A4Y6G3
- Every structure of UniProt A4Y6G1
- Every structure of UniProt A4Y6G2
- Elsewhere: RCSB PDB 5O7H · PDBe 5O7H · UniProt A4Y6G3 · UniProt A4Y6G1 · UniProt A4Y6G2
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