Research workbench
Structure of a bacterial light-regulated adenylyl cyclase
Analyse Structure of a bacterial light-regulated adenylyl cyclase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5MBJ
- Type
- protein
- Length
- 675 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.3
- Source
- Beggiatoa sp. PS
- Molecule
- Beta subunit of photoactivated adenylyl cyclase
- UniProt
- A7BT71
- Ligands
- FMN
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · resolution 2.3 · 2 distinct chains · 43% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta subunit of photoactivated adenylyl cyclase | protein | 338 | 42% helix, 33% strand | A7BT71 |
| B | Beta subunit of photoactivated adenylyl cyclase | protein | 337 | 45% helix, 31% strand | A7BT71 |
Ligands and binding sites
- FMN · Flavin mononucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 694 | 0.71 | 0.78 | 53 | empty |
| 2 | 95 | 0.62 | 0.88 | 17 | FMN |
| 3 | 151 | 0.52 | 0.79 | 26 | empty |
| 4 | 153 | 0.49 | 0.78 | 24 | empty |
| 5 | 195 | 0.49 | 0.76 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 3446 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 5MBJ · Structure of a bacterial light-regulated adenylyl cyclase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A7BT71
- Elsewhere: RCSB PDB 5MBJ · PDBe 5MBJ · UniProt A7BT71
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