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Crystal structure of MtISWI bound with histone H4 tail

Analyse Crystal structure of MtISWI bound with histone H4 tail in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5JXT
Type: protein
Length: 5,087 residues
Chains: 23
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.009
Source: Myceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799)…
Molecule: Chromatin-remodeling complex ATPase-like protein; Histone H4
UniProt: G2QFM3, A0A0E9NAT8
Pockets: 20 · best druggability 0.83

Structure

x-ray diffraction · resolution 3.009 · 18 distinct chains · 52% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Chromatin-remodeling complex ATPase-like protein	protein	328	48% helix, 11% strand	G2QFM3
E	Chromatin-remodeling complex ATPase-like protein	protein	313	56% helix, 11% strand	G2QFM3
F	Chromatin-remodeling complex ATPase-like protein	protein	324	50% helix, 10% strand	G2QFM3
G	Chromatin-remodeling complex ATPase-like protein	protein	308	55% helix, 11% strand	G2QFM3
J	Chromatin-remodeling complex ATPase-like protein	protein	317	51% helix, 10% strand	G2QFM3
N	Chromatin-remodeling complex ATPase-like protein	protein	319	51% helix, 10% strand	G2QFM3
O	Chromatin-remodeling complex ATPase-like protein	protein	322	52% helix, 10% strand	G2QFM3
P	Chromatin-remodeling complex ATPase-like protein	protein	316	51% helix, 10% strand	G2QFM3
R, S, U, Q, T, V	Histone H4	protein	5	0% helix, 0% strand	A0A0E9NAT8
C	Chromatin-remodeling complex ATPase-like protein	protein	324	50% helix, 11% strand	G2QFM3
H	Chromatin-remodeling complex ATPase-like protein	protein	321	50% helix, 10% strand	G2QFM3
K	Chromatin-remodeling complex ATPase-like protein	protein	306	53% helix, 11% strand	G2QFM3
L	Chromatin-remodeling complex ATPase-like protein	protein	311	54% helix, 10% strand	G2QFM3
A	Chromatin-remodeling complex ATPase-like protein	protein	327	51% helix, 10% strand	G2QFM3
I	Chromatin-remodeling complex ATPase-like protein	protein	301	51% helix, 11% strand	G2QFM3
D	Chromatin-remodeling complex ATPase-like protein	protein	292	54% helix, 11% strand	G2QFM3
M	Chromatin-remodeling complex ATPase-like protein	protein	324	51% helix, 10% strand	G2QFM3
W	Histone H4	protein	4	0% helix, 0% strand	A0A0E9NAT8

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	594	0.83	0.88	54	empty
2	589	0.81	0.87	61	empty
3	851	0.77	0.81	102	empty
4	1145	0.77	0.79	102	empty
5	542	0.76	0.84	67	empty

Interfaces

41 interfaces between chains.

E–H · 5227 Å² buried · 54 hydrogen bonds · protein-protein
G–M · 5183 Å² buried · 50 hydrogen bonds · protein-protein
B–K · 5044 Å² buried · 49 hydrogen bonds · protein-protein
J–C · 5021 Å² buried · 48 hydrogen bonds · protein-protein
O–A · 5017 Å² buried · 41 hydrogen bonds · protein-protein

Compared structures

5JXT · Crystal structure of mtiswi bound with histone H4 tail · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G2QFM3
Every structure of UniProt A0A0E9NAT8
Elsewhere: RCSB PDB 5JXT · PDBe 5JXT · UniProt G2QFM3 · UniProt A0A0E9NAT8

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