Research workbench
Streptomyces plicatus N-acetyl-beta-hexosaminidase in complex with Thio-NAglucal (TNX)
Analyse Streptomyces plicatus N-acetyl-beta-hexosaminidase in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5FCZ
- Type
- protein
- Length
- 499 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.45
- Source
- Streptomyces plicatus
- Molecule
- B-N-acetylhexosaminidase
- UniProt
- O85361
- Ligands
- TNX, CL, SO4
- Pockets
- 5 · best druggability 0.55
Structure
x-ray diffraction · resolution 2.45 · 1 distinct chain · 35% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | B-N-acetylhexosaminidase | protein | 499 | 35% helix, 17% strand | O85361 |
Ligands and binding sites
- TNX · 1,5-anhydro-2-deoxy-2-(ethanethioylamino)-D-arabino-hex-1-enitol · sugar · chains A
- CL · Chloride ion · ion · 8 copies · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.55 | 0.86 | 14 | TNX |
| 2 | 141 | 0.46 | 0.77 | 23 | CL |
| 3 | 65 | 0.43 | 0.81 | 16 | empty |
| 4 | 106 | 0.37 | 0.74 | 18 | GOL |
| 5 | 76 | 0.31 | 0.74 | 16 | CL |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5FCZ · Streptomyces plicatus N-acetyl-beta-hexosaminidase in complex with thio-naglucal (tnx) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O85361
- Elsewhere: RCSB PDB 5FCZ · PDBe 5FCZ · UniProt O85361
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.