Research workbench
Crystal structure of Family 31 alpha-glucosidase (BT_3299) from Bacteroides thetaiotaomicron
Analyse Crystal structure of Family 31 alpha-glucosidase (BT_3299) from Bacteroides… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5DJW
- Type
- protein
- Length
- 1,175 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.7
- Source
- Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 /…
- Molecule
- Alpha-glucosidase II
- UniProt
- Q8A2K6
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · resolution 2.7 · 2 distinct chains · 20% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-glucosidase II | protein | 588 | 20% helix, 19% strand | Q8A2K6 |
| B | Alpha-glucosidase II | protein | 587 | 20% helix, 15% strand | Q8A2K6 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 846 | 0.77 | 0.80 | 87 | empty |
| 2 | 83 | 0.73 | 0.96 | 19 | empty |
| 3 | 149 | 0.69 | 0.89 | 32 | empty |
| 4 | 143 | 0.66 | 0.87 | 30 | empty |
| 5 | 203 | 0.64 | 0.84 | 37 | empty |
Interfaces
1 interface between chains.
- A–B · 529 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 isopeptide (isopeptide).
Compared structures
- 5DJW · Crystal structure of family 31 alpha-glucosidase (BT_3299) from bacteroides… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8A2K6
- Elsewhere: RCSB PDB 5DJW · PDBe 5DJW · UniProt Q8A2K6
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