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Structure of a lantibiotic response regulator: N terminal domain of the nisin resistance regulator NsrR

Analyse Structure of a lantibiotic response regulator: N terminal domain of the nisin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5DCL
Type: protein
Length: 234 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.41
Source: Streptococcus agalactiae
Molecule: PhoB family transcriptional regulator
UniProt: X5JZS1
Pockets: 2 · best druggability 0.56

Structure

x-ray diffraction · resolution 1.41 · 1 distinct chain · 41% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	PhoB family transcriptional regulator	protein	117	41% helix, 21% strand	X5JZS1

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 39 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	130	0.56	0.82	20	empty
2	128	0.52	0.80	20	EDO

Interfaces

1 interface between chains.

A–B · 681 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

5DCL · Structure of a lantibiotic response regulator: N terminal domain of the nisin resistance… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt X5JZS1
Elsewhere: RCSB PDB 5DCL · PDBe 5DCL · UniProt X5JZS1

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