Research workbench
E. coli MazF mutant E24A in complex with MazE residues 68-82 form II
Analyse E. coli MazF mutant E24A in complex with MazE residues 68-82 form II in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5CQY
- Type
- protein
- Length
- 219 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.481
- Source
- Escherichia coli K-12; SYNTHETIC CONSTRUCT
- Molecule
- Endoribonuclease MazF; Antitoxin MazE
- EC
- 3.1.27.-
- UniProt
- P0AE70, P0AE72
- Pockets
- 1 · best druggability 0.27
Structure
x-ray diffraction · resolution 2.481 · 3 distinct chains · 23% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endoribonuclease MazF (EC 3.1.27.-) | protein | 102 | 24% helix, 32% strand | P0AE70 |
| B | Endoribonuclease MazF (EC 3.1.27.-) | protein | 102 | 25% helix, 35% strand | P0AE70 |
| C | Antitoxin MazE | protein | 15 | 0% helix, 0% strand | P0AE72 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.27 | 0.73 | 17 | empty |
Interfaces
3 interfaces between chains.
- A–B · 889 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 663 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 459 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5CQY · E. COLI mazf mutant E24A in complex with maze residues 68-82 form II · the same entry in another collection · chain A against A, TM-score 1.00
- P0AE70 · AlphaFold monomer V2.0 prediction for endoribonuclease toxin mazf (P0AE70) · a predicted model of the same protein · chain B against A, TM-score 0.93
- P0AE72 · AlphaFold monomer V2.0 prediction for antitoxin maze (P0AE72) · a predicted model of the same protein · chain C against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AE70
- Every structure of UniProt P0AE72
- Elsewhere: RCSB PDB 5CQY · PDBe 5CQY · UniProt P0AE70 · UniProt P0AE72
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