Research workbench
Merlin-FERM and Lats1 complex
Analyse Merlin-FERM and Lats1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ZRK
- Type
- protein
- Length
- 1,258 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.316
- Source
- Homo sapiens; Mus musculus
- Molecule
- Merlin; Serine/threonine-protein kinase LATS1
- UniProt
- P46662, O95835
- Pockets
- 20 · best druggability 0.62
Structure
x-ray diffraction · resolution 2.316 · 5 distinct chains · 38% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Merlin | protein | 292 | 36% helix, 24% strand | P46662 |
| B, D | Merlin | protein | 293 | 37% helix, 25% strand | P46662 |
| C | Merlin | protein | 295 | 37% helix, 25% strand | P46662 |
| E, F, H | Serine/threonine-protein kinase LATS1 | protein | 21 | 57% helix, 0% strand | O95835 |
| G | Serine/threonine-protein kinase LATS1 | protein | 22 | 68% helix, 5% strand | O95835 |
Pockets
20 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 417 | 0.62 | 0.76 | 46 | empty |
| 2 | 331 | 0.60 | 0.77 | 32 | empty |
| 3 | 347 | 0.59 | 0.77 | 35 | empty |
| 4 | 257 | 0.56 | 0.77 | 31 | empty |
| 5 | 138 | 0.46 | 0.77 | 20 | empty |
Interfaces
8 interfaces between chains.
- C–G · 741 Ų buried · 5 hydrogen bonds · protein-protein
- A–E · 735 Ų buried · 2 hydrogen bonds · protein-protein
- D–H · 721 Ų buried · 3 hydrogen bonds · protein-protein
- B–F · 685 Ų buried · 4 hydrogen bonds · protein-protein
- C–E · 511 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 4ZRK · Merlin-ferm and LATS1 complex · the same entry in another collection · chain H against H, TM-score 1.00
- P46662 · AlphaFold monomer V2.0 prediction for merlin (P46662) · a predicted model of the same protein · chain B against A, TM-score 0.98
- O95835 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase LATS1 (O95835) · a predicted model of the same protein · chain G against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46662
- Every structure of UniProt O95835
- Elsewhere: RCSB PDB 4ZRK · PDBe 4ZRK · UniProt P46662 · UniProt O95835
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.