Research workbench
Crystal structure of ferret interleukin-2
Analyse Crystal structure of ferret interleukin-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ZF7
- Type
- protein
- Length
- 253 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.893
- Source
- Mustela putorius furo
- Molecule
- Interleukin 2
- UniProt
- A3FBE6
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · resolution 1.893 · 2 distinct chains · 68% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin 2 | protein | 126 | 68% helix, 5% strand | A3FBE6 |
| B | Interleukin 2 | protein | 127 | 68% helix, 9% strand | A3FBE6 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
- PG4 · Tetraethylene glycol · additive · 2 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
- 1PE · Pentaethylene glycol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 105 | 0.44 | 0.78 | 20 | empty |
| 2 | 85 | 0.34 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 652 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4ZF7 · Crystal structure of ferret interleukin-2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A3FBE6
- Elsewhere: RCSB PDB 4ZF7 · PDBe 4ZF7 · UniProt A3FBE6
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