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Structural and biochemical characterization of a non-functionally redundant M. tuberculosis (3,3) L,D-Transpeptidase, LdtMt5.

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PDB: 4Z7A
Type: protein
Length: 355 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.98
Source: Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Molecule: Mycobacterium tuberculosis (3,3)L,D-Transpeptidase type 5
UniProt: A5TZL1
Ligands: ACE, PO4
Pockets: 2 · best druggability 0.41

Structure

x-ray diffraction · resolution 1.98 · 1 distinct chain · 9% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mycobacterium tuberculosis (3,3)L,D-Transpeptidase type 5	protein	355	9% helix, 43% strand	A5TZL1

Ligands and binding sites

ACE · Acetyl group · ligand · chains A
PO4 · Phosphate ion · ion · chains A
PEG · Di(hydroxyethyl)ether · additive · chains A
PGE · Triethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.41	0.80	23	empty
2	53	0.25	0.72	14	empty

Compared structures

4Z7A · Structural and biochemical characterization of a non-functionally redundant M.… · the same entry in another collection · chain A against A, TM-score 1.00

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Every structure of UniProt A5TZL1
Elsewhere: RCSB PDB 4Z7A · PDBe 4Z7A · UniProt A5TZL1

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