Research workbench
Crystal Structure Analysis of BST-1/CD157 complexed with ethenoNADP
Analyse Crystal Structure Analysis of BST-1/CD157 complexed with ethenoNADP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ISH
- Type
- protein
- Length
- 500 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.4
- Source
- Homo sapiens
- Molecule
- bone marrow stromal cell antigen 1
- EC
- 3.2.2.5
- UniProt
- Q10588
- Ligands
- ENP, NAG
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · resolution 2.4 · 1 distinct chain · 42% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | bone marrow stromal cell antigen 1 (EC 3.2.2.5) | protein | 250 | 42% helix, 13% strand | Q10588 |
Ligands and binding sites
- ENP · Etheno-nadp · ligand · 2 copies · chains A, B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1123 | 0.77 | 0.79 | 88 | empty |
| 2 | 250 | 0.58 | 0.78 | 35 | ENP |
| 3 | 208 | 0.57 | 0.80 | 19 | ENP |
Interfaces
1 interface between chains.
- A–B · 1368 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 1ISH · Crystal structure analysis of bst-1/CD157 complexed with ethenonadp · the same entry in another collection · chain A against A, TM-score 1.00
- Q10588 · AlphaFold monomer V2.0 prediction for ADP-ribosyl CYCLASE/CYCLIC ADP- ribose hydrolase 2… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q10588
- Elsewhere: RCSB PDB 1ISH · PDBe 1ISH · UniProt Q10588
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