Research workbench
Crystal structure of the FP domain of Human PI31 Proteasome Inhibitor
Analyse Crystal structure of the FP domain of Human PI31 Proteasome Inhibitor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OUH
- Type
- protein
- Length
- 591 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2
- Source
- Homo sapiens
- Molecule
- Proteasome inhibitor PI31 subunit
- UniProt
- Q92530
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · resolution 2 · 4 distinct chains · 37% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proteasome inhibitor PI31 subunit | protein | 149 | 38% helix, 27% strand | Q92530 |
| B | Proteasome inhibitor PI31 subunit | protein | 148 | 38% helix, 26% strand | Q92530 |
| C | Proteasome inhibitor PI31 subunit | protein | 147 | 33% helix, 27% strand | Q92530 |
| D | Proteasome inhibitor PI31 subunit | protein | 147 | 38% helix, 27% strand | Q92530 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1178 | 0.73 | 0.77 | 104 | empty |
| 2 | 198 | 0.53 | 0.78 | 24 | empty |
| 3 | 169 | 0.51 | 0.78 | 24 | empty |
| 4 | 197 | 0.50 | 0.76 | 22 | empty |
Interfaces
5 interfaces between chains.
- A–B · 635 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 625 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 169 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 160 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 94 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4OUH · Crystal structure of the fp domain of human PI31 proteasome inhibitor · the same entry in another collection · chain D against D, TM-score 1.00
- Q92530 · AlphaFold monomer V2.0 prediction for proteasome inhibitor PI31 subunit (Q92530) · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92530
- Elsewhere: RCSB PDB 4OUH · PDBe 4OUH · UniProt Q92530
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