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Crystal structure of a GNAT superfamily acetyltransferase PA4794 C29A/C117A/Y128A mutant in complex with chloramphenicol

Analyse Crystal structure of a GNAT superfamily acetyltransferase PA4794… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4OAE
Type: protein
Length: 160 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.25
Source: Pseudomonas aeruginosa
Molecule: GNAT superfamily acetyltransferase PA4794
UniProt: Q9HV14
Ligands: CLM, SO4
Pockets: 1 · best druggability 0.72

Structure

x-ray diffraction · resolution 1.25 · 1 distinct chain · 34% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	GNAT superfamily acetyltransferase PA4794	protein	160	34% helix, 37% strand	Q9HV14

Ligands and binding sites

CLM · Chloramphenicol · ligand · 2 copies · chains A
SO4 · Sulfate ion · ion · 6 copies · chains A
EDO · 1,2-ethanediol · additive · 8 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	440	0.72	0.82	49	SO4, CLM, EDO

Compared structures

4OAE · Crystal structure of a gnat superfamily acetyltransferase PA4794 C29A/C117A/Y128A mutant… · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HV14
Elsewhere: RCSB PDB 4OAE · PDBe 4OAE · UniProt Q9HV14

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