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Structure of PF2046

Analyse Structure of PF2046 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4O8U
Type: protein
Length: 1,362 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.345
Source: Pyrococcus furiosus
Molecule: Uncharacterized protein PF2046
UniProt: Q8TZE9
Pockets: 18 · best druggability 0.58

Structure

x-ray diffraction · resolution 2.345 · 1 distinct chain · 33% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Uncharacterized protein PF2046	protein	227	33% helix, 32% strand	Q8TZE9

Pockets

18 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	406	0.58	0.75	47	empty
2	396	0.57	0.75	48	empty
3	338	0.57	0.76	39	empty
4	388	0.57	0.75	47	empty
5	385	0.56	0.74	47	empty

Interfaces

9 interfaces between chains.

B–E · 819 Å² buried · 13 hydrogen bonds · protein-protein
C–D · 809 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 807 Å² buried · 13 hydrogen bonds · protein-protein
A–E · 807 Å² buried · 12 hydrogen bonds · protein-protein
C–F · 803 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 18 modified (engineered).

Compared structures

4O8U · Structure of PF2046 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TZE9
Elsewhere: RCSB PDB 4O8U · PDBe 4O8U · UniProt Q8TZE9

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