Research workbench
Crystal structure of the first bromodomain of human BRD4 in complex with SB 202190
Analyse Crystal structure of the first bromodomain of human BRD4 in complex with SB… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4O77
- Type
- protein
- Length
- 254 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2
- Source
- Homo sapiens
- Molecule
- Bromodomain-containing protein 4
- UniProt
- O60885
- Ligands
- 2RE
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · resolution 2 · 1 distinct chain · 54% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Bromodomain-containing protein 4 | protein | 127 | 54% helix, 0% strand | O60885 |
Ligands and binding sites
- 2RE · 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 361 | 0.64 | 0.79 | 47 | empty |
| 2 | 105 | 0.53 | 0.83 | 17 | 2RE |
| 3 | 98 | 0.51 | 0.82 | 17 | 2RE |
Interfaces
1 interface between chains.
- A–B · 361 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4O77 · Crystal structure of the first bromodomain of human BRD4 in complex with sb 202190 · the same entry in another collection · chain A against A, TM-score 1.00
- O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60885
- Elsewhere: RCSB PDB 4O77 · PDBe 4O77 · UniProt O60885
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