Research workbench
Crystal structure of the major pollen allergen Bet v 1-A in complex with P303
Analyse Crystal structure of the major pollen allergen Bet v 1-A in complex with P303 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MNS
- Type
- protein
- Length
- 159 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.2
- Source
- Betula pendula
- Molecule
- Major pollen allergen Bet v 1-A
- UniProt
- P15494
- Ligands
- 2AX
- Pockets
- 2 · best druggability 0.83
Structure
x-ray diffraction · resolution 1.2 · 1 distinct chain · 26% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major pollen allergen Bet v 1-A | protein | 159 | 26% helix, 40% strand | P15494 |
Ligands and binding sites
- 2AX · (3R,4R,5aR,11aR)-3-methyl-6,11-dioxo-2,3,4,5,5a,6,11,11a-octahydrothiepino[3,2-g]isoquinoline-4-carboxylic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 498 | 0.83 | 0.89 | 56 | 2AX |
| 2 | 52 | 0.30 | 0.76 | 15 | empty |
Compared structures
- 4MNS · Crystal structure of the major pollen allergen bet V 1-a in complex with P303 · the same entry in another collection · chain A against A, TM-score 1.00
- P15494 · AlphaFold monomer V2.0 prediction for major pollen allergen bet V 1-a (P15494) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15494
- Elsewhere: RCSB PDB 4MNS · PDBe 4MNS · UniProt P15494
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