Research workbench
AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase cbl-C (Q9ULV8)
Analyse AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase cbl-C (Q9ULV8) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9ULV8
- Type
- protein
- Length
- 474 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xbDA05C32aD6eE153C8C5A78dfa48d7Ba25694fea
- Molecule
- E3 ubiquitin-protein ligase cbl-C
- UniProt
- Q9ULV8
- Pockets
- 7 · best druggability 0.66
Structure
1 distinct chain · 41% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase cbl-C | protein | 474 | 41% helix, 10% strand | Q9ULV8 |
Pockets
7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 103 | 0.66 | 0.90 | 30 | empty |
| 2 | 133 | 0.65 | 0.87 | 21 | empty |
| 3 | 270 | 0.59 | 0.78 | 25 | empty |
| 4 | 165 | 0.53 | 0.79 | 20 | empty |
| 5 | 270 | 0.52 | 0.75 | 29 | empty |
Compared structures
- 3OP0 · Crystal structure of cbl-C (cbl-3) tkb domain in complex with EGFR PY1069 peptide · an experimental structure of the same protein · chain A against B, TM-score 0.66
- 3OP0 · Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide · an experimental structure of the same protein · chain A against B, TM-score 0.66
- 3VRP · Crystal structure of the tyrosine kinase binding domain of Cbl-c in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.60
- 3VRP · Crystal structure of the tyrosine kinase binding domain of cbl-C in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.60
- 3VRR · Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant) in complex… · an experimental structure of the same protein · chain A against A, TM-score 0.60
- 3VRR · Crystal structure of the tyrosine kinase binding domain of cbl-C (pl mutant) in complex… · an experimental structure of the same protein · chain A against A, TM-score 0.60
- 3VRN · Crystal structure of the tyrosine kinase binding domain of cbl-C · an experimental structure of the same protein · chain A against A, TM-score 0.60
- 3VRN · Crystal structure of the tyrosine kinase binding domain of Cbl-c · an experimental structure of the same protein · chain A against A, TM-score 0.60
- 3VRO · Crystal structure of the tyrosine kinase binding domain of Cbl-c in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.59
- 3VRO · Crystal structure of the tyrosine kinase binding domain of cbl-C in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ULV8
- Elsewhere: UniProt Q9ULV8 · AlphaFold DB Q9ULV8
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