Research workbench
AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase cbl-B (Q8K4S7)
Analyse AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase cbl-B (Q8K4S7) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q8K4S7
- Type
- protein
- Length
- 938 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xC0491A7e4a5851164cEffD648c5067B32B6C2422
- Molecule
- E3 ubiquitin-protein ligase cbl-B
- UniProt
- Q8K4S7
- Pockets
- 3 · best druggability 0.78
Structure
1 distinct chain · 26% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase cbl-B | protein | 938 | 26% helix, 5% strand | Q8K4S7 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1027 | 0.78 | 0.80 | 82 | empty |
| 2 | 560 | 0.68 | 0.77 | 74 | empty |
| 3 | 52 | 0.28 | 0.75 | 13 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8K4S7
- Elsewhere: UniProt Q8K4S7 · AlphaFold DB Q8K4S7
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