AlphaFold monomer V2.0 prediction for tyrosyl-DNA phosphodiesterase 2 (Q9JJX7)

Structure

1 distinct chain · 26% helix, 25% strand (DSSP).

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 4PUQ · Mus musculus TDP2 reaction product complex with 5'-phosphorylated RNA/DNA, glycerol, and… · an experimental structure of the same protein · chain A against A, TM-score 0.68
• 4PUQ · Mus Musculus Tdp2 reaction product complex with 5'-phosphorylated RNA/DNA, glycerol, and… · an experimental structure of the same protein · chain A against A, TM-score 0.68
• 5INQ · Mouse TDP2 reaction product (5'-phosphorylated DNA)-CA2+ complex · an experimental structure of the same protein · chain A against A, TM-score 0.68
• 5INQ · Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Ca2+ complex · an experimental structure of the same protein · chain A against A, TM-score 0.68
• 5INP · Mouse TDP2 reaction product (5'-phosphorylated DNA)-MN2+ complex · an experimental structure of the same protein · chain A against A, TM-score 0.68
• 5INK · Mouse Tdp2 reaction product (5'-phosphorylated DNA)-abasic/THF-Mg2+ complex · an experimental structure of the same protein · chain A against A, TM-score 0.68
• 5INK · Mouse TDP2 reaction product (5'-phosphorylated DNA)-ABASIC/THF-MG2+ complex · an experimental structure of the same protein · chain A against A, TM-score 0.68
• 5HT2 · Mouse TDP2 reaction product (5'-phosphorylated DNA)-MG2+ complex with 1-N6-etheno-adenine · an experimental structure of the same protein · chain A against A, TM-score 0.68
• 5INL · Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex with deoxyadenosine · an experimental structure of the same protein · chain A against A, TM-score 0.68
• 5INL · Mouse TDP2 reaction product (5'-phosphorylated DNA)-MG2+ complex with deoxyadenosine · an experimental structure of the same protein · chain A against A, TM-score 0.68
• 5TVP · SUMO2 bound to mouse TDP2 catalytic domain with a 5'-phosphorylated DNA ternary complex · an experimental structure of the same protein · chain A against B, TM-score 0.68
• 4GZ1 · Mus Musculus Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex at 1.5 Angstroms… · an experimental structure of the same protein · chain A against A, TM-score 0.68

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9JJX7
• Elsewhere: UniProt Q9JJX7 · AlphaFold DB Q9JJX7