Research workbench
AlphaFold monomer V2.0 prediction for thermolysin (P43133)
Analyse AlphaFold monomer V2.0 prediction for thermolysin (P43133) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P43133
- Type
- protein
- Length
- 551 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x738c1929c69B751bD0Be0B962D9bac20B631aAc6
- Molecule
- Thermolysin
- UniProt
- P43133
- Pockets
- 6 · best druggability 0.65
Structure
1 distinct chain · 32% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thermolysin | protein | 551 | 32% helix, 27% strand | P43133 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 427 | 0.65 | 0.78 | 37 | empty |
| 2 | 341 | 0.64 | 0.80 | 31 | empty |
| 3 | 233 | 0.54 | 0.77 | 38 | empty |
| 4 | 168 | 0.49 | 0.77 | 24 | empty |
| 5 | 75 | 0.42 | 0.80 | 23 | empty |
Compared structures
- 5WR5 · Thermolysin, liganded form with cryo condition 1 · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 5WR5 · Thermolysin, liganded form with cryo condition 1 · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 6FSM · Crystal structure of TCE-treated Thermolysin · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 6FSM · Crystal structure of tce-treated thermolysin · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 5WR6 · Thermolysin, liganded form with cryo condition 2 · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 5WR6 · Thermolysin, liganded form with cryo condition 2 · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 6YI6 · Structural and Kinetic Evaluation of Phosphoramidate Inhibitors on Thermolysin · an experimental structure of the same protein · chain A against E, TM-score 0.57
- 6YI6 · Structural and kinetic evaluation of phosphoramidate inhibitors on thermolysin · an experimental structure of the same protein · chain A against E, TM-score 0.57
- 6Y4I · Structural and kinetic evaluation of phosphoramidate inhibitors on thermolysin · an experimental structure of the same protein · chain A against E, TM-score 0.57
- 6Y4I · Structural and Kinetic Evaluation of Phosphoramidate Inhibitors on Thermolysin · an experimental structure of the same protein · chain A against E, TM-score 0.57
- 5WR2 · Thermolysin, SFX liganded form with oil-based carrier · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 5WR2 · Thermolysin, sfx liganded form with oil-based carrier · an experimental structure of the same protein · chain A against A, TM-score 0.57
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43133
- Elsewhere: UniProt P43133 · AlphaFold DB P43133
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