Research workbench
AlphaFold monomer V2.0 prediction for N-lysine methyltransferase SMYD2 (Q9NRG4)
Analyse AlphaFold monomer V2.0 prediction for N-lysine methyltransferase SMYD2 (Q9NRG4) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9NRG4
- Type
- protein
- Length
- 433 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB44F19a0cb161828322eEEd13F55d4C3C34938d2
- Molecule
- N-lysine methyltransferase SMYD2
- UniProt
- Q9NRG4
- Pockets
- 3 · best druggability 0.78
Structure
1 distinct chain · 50% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | N-lysine methyltransferase SMYD2 | protein | 433 | 50% helix, 14% strand | Q9NRG4 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 795 | 0.78 | 0.82 | 89 | empty |
| 2 | 84 | 0.45 | 0.80 | 14 | empty |
| 3 | 87 | 0.41 | 0.78 | 17 | empty |
Compared structures
- 6N3G · Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene… · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 6N3G · Crystal structure of histone lysine methyltransferase SMYD2 in complex with polyethylene… · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 3S7F · Structural Basis of Substrate Methylation and Inhibition of SMYD2 · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 3S7F · Structural basis of substrate methylation and inhibition of SMYD2 · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 3S7B · Structural basis of substrate methylation and inhibition of SMYD2 · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 3S7B · Structural Basis of Substrate Methylation and Inhibition of SMYD2 · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 6MON · Crystal structure of human SMYD2 in complex with Nle-peptide inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 6MON · Crystal structure of human SMYD2 in complex with nle-peptide inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 5KJK · SMYD2 in complex with AZ370 · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 5KJK · SMYD2 in complex with AZ370 · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 5KJM · SMYD2 in complex with AZ931 · an experimental structure of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NRG4
- Elsewhere: UniProt Q9NRG4 · AlphaFold DB Q9NRG4
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