Research workbench
AlphaFold monomer V2.0 prediction for mothers against decapentaplegic homolog 2 (Q15796)
Analyse AlphaFold monomer V2.0 prediction for mothers against decapentaplegic homolog 2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q15796
- Type
- protein
- Length
- 467 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9e5E98E011361C5888c92e2CDb7652E02Bd5C7Ed
- Molecule
- Mothers against decapentaplegic homolog 2
- UniProt
- Q15796
- Pockets
- 5 · best druggability 0.64
Structure
1 distinct chain · 26% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mothers against decapentaplegic homolog 2 | protein | 467 | 26% helix, 18% strand | Q15796 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 522 | 0.64 | 0.76 | 68 | empty |
| 2 | 450 | 0.61 | 0.75 | 54 | empty |
| 3 | 83 | 0.33 | 0.74 | 18 | empty |
| 4 | 56 | 0.27 | 0.73 | 15 | empty |
| 5 | 62 | 0.26 | 0.73 | 11 | empty |
Compared structures
- 1KHX · Crystal structure of a phosphorylated SMAD2 · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 1KHX · Crystal structure of a phosphorylated Smad2 · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 6ZVQ · Complex between SMAD2 MH2 domain and peptide from ski corepressor · an experimental structure of the same protein · chain A against A, TM-score 0.42
- 6ZVQ · Complex between SMAD2 MH2 domain and peptide from Ski corepressor · an experimental structure of the same protein · chain A against A, TM-score 0.42
- 6M64 · Crystal structure of SMAD2 in complex with cbp · an experimental structure of the same protein · chain A against A, TM-score 0.42
- 6M64 · Crystal structure of SMAD2 in complex with CBP · an experimental structure of the same protein · chain A against A, TM-score 0.42
- 1U7V · Crystal structure of the phosphorylated SMAD2/SMAD4 heterotrimeric complex · an experimental structure of the same protein · chain A against A, TM-score 0.42
- 1U7V · Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex · an experimental structure of the same protein · chain A against A, TM-score 0.42
- 1DEV · Crystal structure of SMAD2 MH2 domain bound to the smad-binding domain of sara · an experimental structure of the same protein · chain A against A, TM-score 0.41
- 1DEV · Crystal structure of SMAD2 MH2 domain bound to the smad-binding domain of sara · an experimental structure of the same protein · chain A against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15796
- Elsewhere: UniProt Q15796 · AlphaFold DB Q15796
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