Research workbench
AlphaFold monomer V2.0 prediction for solute carrier family 15 member 2 (Q63424)
Analyse AlphaFold monomer V2.0 prediction for solute carrier family 15 member 2 (Q63424) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q63424
- Type
- protein
- Length
- 729 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x30b967CB2B3168F5Aa05Ec10C8CFFa3D82E84396
- Molecule
- Solute carrier family 15 member 2
- UniProt
- Q63424
- Pockets
- 7 · best druggability 0.79
Structure
1 distinct chain · 51% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Solute carrier family 15 member 2 | protein | 729 | 51% helix, 18% strand | Q63424 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 999 | 0.79 | 0.80 | 70 | empty |
| 2 | 392 | 0.69 | 0.81 | 53 | empty |
| 3 | 141 | 0.46 | 0.77 | 29 | empty |
| 4 | 112 | 0.42 | 0.76 | 16 | empty |
| 5 | 124 | 0.41 | 0.75 | 24 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7NQK · Cryo-EM structure of the mammalian peptide transporter PEPT2 · an experimental structure of the same protein · chain A against A, TM-score 0.60
- 7NQK · Cryo-EM structure of the mammalian peptide transporter PepT2 · an experimental structure of the same protein · chain A against A, TM-score 0.60
- 9BIR · Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cefadroxil · an experimental structure of the same protein · chain A against A, TM-score 0.52
- 9BIT · Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 1 · an experimental structure of the same protein · chain A against A, TM-score 0.52
- 9BIU · Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 2 · an experimental structure of the same protein · chain A against A, TM-score 0.52
- 9BIS · Cryo-EM structure of the mammalian peptide transporter PepT2 bound to amoxicillin · an experimental structure of the same protein · chain A against A, TM-score 0.52
- 5A9I · Crystal structure of the extracellular domain of PepT2 · an experimental structure of the same protein · chain A against A, TM-score 0.26
- 5A9I · Crystal structure of the extracellular domain of PEPT2 · an experimental structure of the same protein · chain A against A, TM-score 0.26
- 5A9H · Crystal structure of the extracellular domain of PEPT2 · an experimental structure of the same protein · chain A against A, TM-score 0.25
- 5A9H · Crystal structure of the extracellular domain of PepT2 · an experimental structure of the same protein · chain A against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q63424
- Elsewhere: UniProt Q63424 · AlphaFold DB Q63424
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