AlphaFold monomer V2.0 prediction for renin (P00797)

Structure

1 distinct chain · 15% helix, 37% strand (DSSP).

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

• 4AMT · Crystal structure at 2.6A of human prorenin · an experimental structure of the same protein · chain A against A, TM-score 0.84
• 3Q5H · Clinically Useful Alkyl Amine Renin Inhibitors · an experimental structure of the same protein · chain A against B, TM-score 0.81
• 3Q3T · Alkyl Amine Renin Inhibitors: Filling S1 from S3 · an experimental structure of the same protein · chain A against A, TM-score 0.81
• 5V8V · Crystal Structure of Human Renin in Complex with a biphenylpipderidinylcarbinol · an experimental structure of the same protein · chain A against B, TM-score 0.81
• 3Q4B · Clinically Useful Alkyl Amine Renin Inhibitors · an experimental structure of the same protein · chain A against A, TM-score 0.81
• 3KM4 · Optimization of Orally Bioavailable Alkyl Amine Renin Inhibitors · an experimental structure of the same protein · chain A against A, TM-score 0.81
• 3GW5 · Crystal structure of human renin complexed with a novel inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.81
• 7XGP · Human renin in complex with compound3 · an experimental structure of the same protein · chain A against B, TM-score 0.81
• 7XGO · Human renin in complex with compound2 · an experimental structure of the same protein · chain A against B, TM-score 0.81
• 7XGK · Human renin in complex with compound1 · an experimental structure of the same protein · chain A against B, TM-score 0.81

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00797
• Elsewhere: UniProt P00797 · AlphaFold DB P00797