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AlphaFold monomer V2.0 prediction for RBAP48-related WD40 repeat- containing protein PRW1 (O14021)

Analyse AlphaFold monomer V2.0 prediction for RBAP48-related WD40 repeat- containing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: O14021
Type: protein
Length: 431 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xb31ae201d13A29F9351985f4eeF3179FD9486ab5
Molecule: RBAP48-related WD40 repeat-containing protein PRW1
UniProt: O14021
Pockets: 5 · best druggability 0.69

Structure

1 distinct chain · 15% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RBAP48-related WD40 repeat-containing protein PRW1	protein	431	15% helix, 42% strand	O14021

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	277	0.69	0.84	33	empty
2	255	0.59	0.79	25	empty
3	90	0.36	0.75	21	empty
4	102	0.34	0.73	20	empty
5	59	0.33	0.77	14	empty

Compared structures

8I03 · Cryo-EM structure of the SIN3L complex from S. pombe · an experimental structure of the same protein · chain A against K, TM-score 0.89
8IFG · Cryo-EM structure of the Clr6S (Clr6-HDAC) complex from S. pombe · an experimental structure of the same protein · chain A against B, TM-score 0.87
8I02 · Cryo-EM structure of the SIN3S complex from S. pombe · an experimental structure of the same protein · chain A against C, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14021
Elsewhere: UniProt O14021 · AlphaFold DB O14021

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