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AlphaFold monomer V2.0 prediction for 5'-3' exonuclease PLD3 (Q8IV08)

Analyse AlphaFold monomer V2.0 prediction for 5'-3' exonuclease PLD3 (Q8IV08) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession
Q8IV08
Type
protein
Length
490 residues
Chains
1
Collection
MolNFT v1 / AlphaFold
Contract
0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner
0xf4ED13986579E8e227b3ED6c02276c648754EC27
Molecule
5'-3' exonuclease PLD3
UniProt
Q8IV08
Pockets
3 · best druggability 0.59

Structure

1 distinct chain · 34% helix, 23% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A5'-3' exonuclease PLD3protein49034% helix, 23% strandQ8IV08

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
13680.590.7639empty
22160.570.7932empty
3510.280.7514empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

  • 8Q1K · Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5'… · an experimental structure of the same protein · chain A against B, TM-score 0.84
  • 8Q1X · Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5'… · an experimental structure of the same protein · chain A against A, TM-score 0.84
  • 8V5T · Crystal structure of Alzheimers disease phospholipase D3 · an experimental structure of the same protein · chain A against A, TM-score 0.84
  • 8S86 · human PLD3 homodimer structure · an experimental structure of the same protein · chain A against B, TM-score 0.79

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