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AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (P24135)

Analyse AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: P24135
Type: protein
Length: 1,265 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xBeB220F0B5b0C48F46B5DDd3E3b071BC0827f8D6
Molecule: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
UniProt: P24135
Pockets: 16 · best druggability 0.80

Structure

1 distinct chain · 32% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	protein	1265	32% helix, 27% strand	P24135

Pockets

16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1152	0.80	0.82	125	empty
2	1197	0.75	0.78	78	empty
3	908	0.70	0.75	79	empty
4	475	0.60	0.75	44	empty
5	172	0.59	0.82	22	empty

Compared structures

2EOB · Solution structure of the second SH2 domain from rat PLC gamma-2 · an experimental structure of the same protein · chain A against A, TM-score 0.09
2EOB · Solution structure of the second SH2 domain from rat plc gamma-2 · an experimental structure of the same protein · chain A against A, TM-score 0.09

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P24135
Elsewhere: UniProt P24135 · AlphaFold DB P24135

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